Pharmacokinetics of norfloxacin in healthy volunteers and patients with renal and hepatic damage
| Autor: | L. Leone, M. Eandi, E. Genazzani, I. Viano, F. Di Nola |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Metabolic Clearance Rate Urinary system Urine Pharmacology urologic and male genital diseases Microbiology High-performance liquid chromatography Gastroenterology Single oral dose Nalidixic Acid Anti-Infective Agents Hepatic damage Pharmacokinetics Internal medicine Healthy volunteers Humans Medicine Norfloxacin Aged business.industry General Medicine Middle Aged Hepatitis B Kinetics Infectious Diseases Kidney Failure Chronic Female business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology. 2:253-259 |
| ISSN: | 1435-4373 0722-2211 |
| DOI: | 10.1007/bf02029528 |
| Popis: | The pharmacokinetics of norfloxacin were studied in six healthy volunteers, and three patients each with moderate renal and hepatic damage. A new specific and sensitive high performance liquid chromatography method was set up to measure plasma and urine concentrations of norfloxacin. The mean urinary concentrations after a single oral dose of 400 mg norfloxacin exceeded many times the MIC and MBC values of most of the bacterial strains responsible for urinary tract infections. Results in the patients with hepatic and renal damage indicated slight and not statistically significant differences in comparison with healthy volunteers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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