Peroxisome proliferation of hepatocytes in rats by a microbial degradation product of cholic acid, 4-(decahydro-6-methyl-3-oxocyclopenta(f)quinoline-7-yl)valeric acid
| Autor: | Yuzo Hayashi, Takayoshi Imazawa, Jun Takahashi, Yuji Kurokawa, Hidetaka Sato, Shohei Hayakawa, Tomoko Mogami-Nishimaki, Kazuhiro Toyoda, Hideaki Okamiya |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Valeric acid Peroxisome Proliferation Biology Toxicology Microbodies Pathology and Forensic Medicine chemistry.chemical_compound medicine Valerates Animals Cells Cultured Clofibrate Cholic acid Cell Biology General Medicine Peroxisome Rats Inbred F344 Rats chemistry Biochemistry Hypotriglyceridemia Liver Catalase biology.protein Quinolines Peroxisome proliferator-activated receptor alpha medicine.drug |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 46(2) |
| ISSN: | 0940-2993 |
| Popis: | Summary Three-week oral administration of 4-(decahydro-6-methyl-3-oxo-cyclopenta(f)quinoline-7-yl)valeric acid (32-1328) in the diet supplemented at concentrations of 0.1 % or 0.3 % was associated with hepatomegaly and hypotriglyceridemia in male F344 rats. Electron microscopic examination of the liver revealed a remarkable increase of peroxisomes in hepatocytes both in number and size. Biochemically, there were increased activities of peroxisomal marker enzymes including the heat-labile enoyl-CoA hydratase and catalase while the mitochondrial enoyl-CoA hydratase activity was unchanged after feeding of 32-1328. These findings indicate that 32-1328 can exert peroxisome-proliferating activity to rat liver in a manner similar to typical peroxisome proliferators such as clofibrate or di(2-ethylhexyl) phthalate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|