Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study
| Autor: | Ibrahim Ali Emara, Mona Kamal Saadeldin, Shereen Saeid Elshaer, Mohamad Maged, Amal Kamal Abdel-Aziz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology medicine.medical_treatment lcsh:Medicine Type 2 diabetes White adipose tissue Cardiovascular Medicine Vascular Medicine Biochemistry Cohort Studies chemistry.chemical_compound Endocrinology 0302 clinical medicine Cell Signaling Medicine and Health Sciences Diabetes diagnosis and management Insulin lcsh:Science WNT Signaling Cascade Multidisciplinary Middle Aged Prognosis Signaling Cascades Type 2 Diabetes Cardiovascular Diseases Bone Morphogenetic Proteins Egypt Female Research Article Signal Transduction Adult Genetic Markers medicine.medical_specialty HbA1c Endocrine Disorders 030209 endocrinology & metabolism 03 medical and health sciences Insulin resistance Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Hemoglobin Obesity Risk factor Adaptor Proteins Signal Transducing Diabetic Endocrinology Endocrine Physiology business.industry lcsh:R Case-control study Biology and Life Sciences Proteins Cell Biology Atherosclerosis medicine.disease Hormones Diagnostic medicine Fibronectins 030104 developmental biology Diabetes Mellitus Type 2 ROC Curve chemistry Metabolic Disorders Case-Control Studies Sclerostin lcsh:Q Insulin Resistance business Biomarkers |
| Zdroj: | PLoS ONE, Vol 13, Iss 11, p e0206761 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Diabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs. Notably, this relative risk is reported to be higher in women than men. Endeavors directed towards identifying novel reliable predictive biomarkers are immensely thereby urged to improve the long-term outcome in these diabetic female patients. Sclerostin (SOST) is a Wnt signaling antagonist whereas irisin is a muscle-derived factor released after exercising which enhances browning of white adipose tissue. Emerging lines of evidence hint at potential crosstalk between them and CVDs. The present study aimed to assess the serum levels of SOST and irisin in Egyptian type 2 diabetic (T2DM) female patients with and without atherosclerosis and explore the possible relationship between both markers and other studied parameters among the studied cohorts. In this case-control study, 69 female subjects were enrolled; 39 type 2 diabetes patients with atherosclerosis (T2DM+ATHR), 22 type 2 diabetes patients without atherosclerosis (T2DM-ATHR) and 8 healthy controls. Their serum levels of SOST and irisin were assessed using ELISA. Significant increase in SOST levels were found in T2DM+ATHR compared to T2DM-ATHR and control (259.9 ±17.98 vs. 165.8±13.12 and 142.0±13.31 pg/mL respectively, P |
| Databáze: | OpenAIRE |
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