Reproductive tradeoffs govern sexually dimorphic tubular lysosome induction in Caenorhabditis elegans

Autor:	Cara D. Ramos, K. Adam Bohnert, Alyssa E. Johnson
Rok vydání:	2022
Předmět:	Male Sex Characteristics Physiology Short Communication Reproduction Aquatic Science Sexual Behavior Animal Insect Science Animals Female Animal Science and Zoology Caenorhabditis elegans Caenorhabditis elegans Proteins Lysosomes Molecular Biology Ecology Evolution Behavior and Systematics
Zdroj:	J Exp Biol
ISSN:	1477-9145 0022-0949
DOI:	10.1242/jeb.244282
Popis:	Sex-specific differences in animal behavior commonly reflect unique reproductive interests. In the nematode Caenorhabditis elegans, hermaphrodites can reproduce without a mate and thus prioritize feeding to satisfy the high energetic costs of reproduction. However, males, which must mate to reproduce, sacrifice feeding to prioritize mate-searching behavior. Here, we demonstrate that these behavioral differences influence sexual dimorphism at the organelle level; young males raised on a rich food source show constitutive induction of gut tubular lysosomes, a non-canonical lysosome morphology that forms in the gut of hermaphrodites when food is limited or as animals age. We found that constitutive induction of gut tubular lysosomes in males results from self-imposed dietary restriction through DAF-7/TGFβ, which promotes exploratory behavior. In contrast, age-dependent induction of gut tubular lysosomes in hermaphrodites is stimulated by self-fertilization activity. Thus, separate reproductive tradeoffs influence tubular lysosome induction in each sex, potentially supporting different requirements for reproductive success.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e57f5b1f7b04b016077cd8af15a4c49 https://doi.org/10.1242/jeb.244282 Zobrazit plný text záznamu