T cells expressing high levels of non-major histocompatibility complex (MHC)-restricted cytotoxicity are present in early and late clinical phases of human immunodeficiency virus 1 (HIV-1) infection

Autor: W. A. Andes, R. D. de Shazo, C. B. Daul, J. E. Morgan, N. H. Hyslop
Rok vydání: 1989
Předmět:
Zdroj: Journal of Clinical Immunology. 9:97-102
ISSN: 1573-2592
0271-9142
DOI: 10.1007/bf00916936
Popis: Cytotoxic cells appear to play an important role in host defense against viral infection. In HIV-1 infection there is an expansion of the Leu7-positive lymphocyte population which is associated with cytotoxic activity. Since a form of non-MHC-restricted T-cell cytotoxicity [lectin-dependent cell cytotoxicity (LDCC)] has been reported to be mediated by CD3+Leu7+ cells, we evaluated LDCC and Leu7-positive lymphocyte populations in HIV-1-infected subjects and healthy controls. Both LDCC and percentages of Leu7+CD3+ and Leu7+CD2+ cells were increased in HIV-1-infected individuals as compared to controls. However, the CD3+Leu7+ lymphocyte population was increased to a greater degree than the CD8+Leu7+ population and a minor Leu7+ cell population (Leu7+CD4+) was expanded in the early stages of infection. Lectin-dependent cell cytotoxicity was positively correlated with the percentages of Leu7+CD3+ cells. Thus T-cells with the capacity to mediate high levels of non-MHC-restricted cytotoxicity are present in increased proportions in HIV-1-infected individuals and persist in advanced disease. Further studies are required to see if these cells participate in HIV-specific cytotoxicity or reflect an aberrant, ineffective, or immunologically detrimental response to the virus.
Databáze: OpenAIRE
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