Activation of Lumbar Spinal Wide-Dynamic Range Neurons by a Sanshool Derivative
| Autor: | Carolyn M. Sawyer, Mirela Iodi Carstens, Christopher T. Simons, Jay Patrick Slack, T. Scott McCluskey, Earl Carstens, Stefan Michael Furrer |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Hot Temperature Sensory Receptor Cells Physiology Action Potentials Sensory system Pharmacology Tachyphylaxis Rats Sprague-Dawley chemistry.chemical_compound Isothiocyanates Physical Stimulation medicine Animals Intradermal injection Skin Dose-Response Relationship Drug Chemistry General Neuroscience Lumbosacral Region Articles Allyl isothiocyanate Spinal cord Amides Potassium channel Rats Cold Temperature medicine.anatomical_structure Nonlinear Dynamics Spinal Cord Capsaicin Sensory Thresholds Sensory System Agents |
| Zdroj: | Journal of Neurophysiology. 101:1742-1748 |
| ISSN: | 1522-1598 0022-3077 |
| Popis: | The enigmatic sensation of tingle involves the activation of primary sensory neurons by hydroxy-α-sanshool, a tingly agent in Szechuan peppers, by inhibiting two-pore potassium channels. Central mechanisms mediating tingle sensation are unknown. We investigated whether a stable derivative of sanshool—isobutylalkenyl amide (IBA)—excites wide-dynamic range (WDR) spinal neurons that participate in transmission of chemesthetic information from the skin. In anesthetized rats, the majority of WDR and low-threshold units responded to intradermal injection of IBA in a dose-related manner over a >5-min time course and exhibited tachyphylaxis at higher concentrations (1 and 10%). Almost all WDR and low-threshold units additionally responded to the pungent agents mustard oil (allyl isothiocyanate) and/or capsaicin, prompting reclassification of the low-threshold cells as WDR. The results are discussed in terms of the functional role of WDR neurons in mediating tingle sensation. |
| Databáze: | OpenAIRE |
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