Progressive Transformation of Germinal Centers: A Clinicopathological Study of 42 Japanese Patients
| Autor: | Kazue Hoshi, Satoshi Ban, Shigeo Nakamura, Noriyuki Sakata, Nobuhide Masawa, Kazuhiko Shimizu, Hideaki Itoh, Katsue Yoshida, Shiro Sugihara, Yoshihiro Ohno, Tetsunari Oyama, Shunichi Shimano, Masaru Kojima, Tadashi Motoori, Nobuo Yamane |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Lymphoma B-Cell Adolescent Epidermal Cyst Salivary Gland Diseases Lymphocyte Activation Hyperthyroidism Asymptomatic Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Japan medicine Humans Child music Lymphatic Diseases Lymph node Aged Asthma music.instrument business.industry Age Factors Germinal center Middle Aged Germinal Center medicine.disease Immunohistochemistry Follicular hyperplasia Lymphoma Tonsillitis 030104 developmental biology medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Etiology Female Surgery Anatomy medicine.symptom business |
| Zdroj: | International Journal of Surgical Pathology. 11:101-107 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/106689690301100205 |
| Popis: | To clarify the clinicopathological features of progressive transformation of germinal center (PTGC) unrelated to nodular lymphocyte predominant Hodgkin's lymphoma in Japanese patients, we reviewed 42 cases and compared the results with those of the United States and Germany. Our results were similar to theirs, with male predominance (M/F ratio, 3:1) and the presentation of a solitary asymptomatic enlarged lymph node in the head and neck area as the common features. However, in Japan, PTGC occurs more frequently in elderly patients. In this study, 12 (29%) of the patients with PTGC were aged 60 years or more. Thirteen patients (31%) with lymphadenopathy in the neck and head area had developed localized chronic inflammation (chronic sialoadenitis=4, chronic tonsillitis=3, infectious epidermal cyst=2) or an autoimmune disorder (hyperthyroidism=2 and bronchial asthma=2). None of the patients developed a malignant lymphoma during the follow-up period of 5 to 238 months (median 27 months). Histologically, in a single longitudinal section of the lymph node, the PTGC occupied up to 5% of the total follicles in 22 patients, 5-10% in 10, 10-20% in 7, and more than 20% in 3. In 5 (12%) patients, an association with prominent marginal zone hyperplasia was also noted. This study also indicates that nodal involvement by various low-grade B-cell lymphomas exhibiting marginal zone distribution patterns should be considered as a differential diagnosis of PTGC. Moreover, in Japan, PTGC is thought to be involved in the etiology of florid reactive follicular hyperplasia in elderly patients. |
| Databáze: | OpenAIRE |
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