Effect of a New Immunosuppressive Agent, Fty720, on Survival of Islet Allografts
| Autor: | Masafumi Kogire, Jun Ida, Yoshiyuki Kawakami, Masayuki Imamura, Yuanjun Gu, Wanxing Cui, Toru Yamasaki, Kazutomo Inoue, H. Setoyama, Hiroyuki Hayashi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine T cell medicine.medical_treatment Portal vein Islets of Langerhans Transplantation Biomedical Engineering lcsh:Medicine Pharmacology 03 medical and health sciences 0302 clinical medicine Sphingosine Allograft survival medicine Lewis rats Animals geography Transplantation geography.geographical_feature_category business.industry Fingolimod Hydrochloride lcsh:R Graft Survival Cell Biology Islet Streptozotocin Rats medicine.anatomical_structure 030104 developmental biology Propylene Glycols Rats Inbred Lew Immunology business Immunosuppressive Agents 030217 neurology & neurosurgery medicine.drug Helper t-cells Allotransplantation |
| Zdroj: | Cell Transplantation, Vol 7 (1998) |
| ISSN: | 1555-3892 0963-6897 |
| DOI: | 10.1177/096368979800700409 |
| Popis: | A newly developed immunosuppressant, FTY720, has a unique mechanism that is quite different from those of conventional immunosuppressants, and is presumed to be mediated through decreases in the number of peripheral lymphocytes, especially helper T cells. This study was performed to ascertain whether this innovative drug could prolong islet allograft survival. The donors were inbred Lewis rats and the recipients were ACI rats rendered hyperglycemic with intravenous streptozotocin. In the study group, FTY720 dissolved in distilled water was orally administered at a dose of 5 mg/kg to the recipient ACI rats 1 day before and on the day of grafting. In the control group, only distilled water was orally administered to the recipient ACI rats on the day before and the day of grafting. Two thousand islets were transplanted into the portal vein of the recipient rats in the study and control groups immediately after isolation. The graft survival time in the study group was significantly longer than that in the control group, indicating that FTY720 retains a potent effect on the prolongation of islet allograft survival. FTY720 could become a useful immunosuppressant for future clinical islet allotransplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|