Effectiveness of Led Photobiomodulation Therapy on Treatment With Knee Osteoarthritis
| Autor: | Soraia Salman, Eduardo Santos Trevisan, Laurita dos Santos, Cintia Cristina Santi Martignago, Lívia Assis, Carla Roberta Tim, Juliana Carolina Tarocco, Richard Eloin Liebano |
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| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Statistical difference Urology Physical Therapy Sports Therapy and Rehabilitation Osteoarthritis Chondrocyte Extracellular matrix 03 medical and health sciences Chondrocytes 0302 clinical medicine Low-Level Light Therapy Transforming Growth Factor beta medicine Animals Rats Wistar Collagen Type II Fibrillation business.industry Rehabilitation Osteoarthritis Knee medicine.disease Immunohistochemistry Stifle Disease Models Animal medicine.anatomical_structure medicine.symptom Gait Analysis 0305 other medical science business 030217 neurology & neurosurgery Transforming growth factor |
| Zdroj: | American Journal of Physical Medicine & Rehabilitation. 99:725-732 |
| ISSN: | 1537-7385 0894-9115 |
| Popis: | Objective The present study aimed to evaluate the effectiveness of photobiomodulation therapy by light-emitting diode on osteoarthritis treatment in the knees of rats. Design Twenty male Wistar rats were randomly assigned into two experimental groups: OAC: animals subjected to induction of osteoarthritis, without therapeutic intervention and the group OAL: animals subjected to induction of osteoarthritis treated with light-emitting diode photobiomodulation therapy (850 nm, 200 mW, 6 J). Results The results of gait analysis showed no statistical difference between the groups. The histological findings showed that the OAL group presented abnormal chondrocyte orientation, yet with less irregularities along fibrillation and the joint tissue. Thus, it presented a lower degenerative process when evaluated by the Osteoarthritis Research Society International. Likewise, in the immunohistochemical analysis, the OAL group showed higher collagen 2 and transforming growth factor β immunoexpression when compared with the OAC group. Conclusions Given the above, it is possible to suggest that the photobiomodulation therapy by light-emitting diode had positive effects on the expression of extracellular matrix proteins responsible for synthesis of articular tissue. |
| Databáze: | OpenAIRE |
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