Patterns and predictors of thromboembolic events among patients with gastric cancer

Autor:	Hanin Shaqboua, Dina Braik, Baha' Sharaf, Abdallah Al-Tell, Rawan Mustafa, Hikmat Abdel-Razeq, Saba Jaradat, Rayan Bater, Razan Mansour, Khaled Ashouri, Jamil Qarqash, Kholoud Alqasem, Zaid Omari
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Disease Adenocarcinoma 030204 cardiovascular system & hematology Risk Assessment Article 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms Thromboembolism Internal medicine medicine Humans cardiovascular diseases lcsh:Science Cancer Retrospective Studies Venous Thrombosis Chemotherapy Multidisciplinary Framingham Risk Score business.industry lcsh:R Anticoagulants Retrospective cohort study Venous Thromboembolism Middle Aged Prognosis medicine.disease equipment and supplies Pulmonary embolism Oncology 030220 oncology & carcinogenesis Ambulatory Female lcsh:Q Pulmonary Embolism business Risk assessment
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-75719-w
Popis:	Patients with gastric cancer are at higher risk for venous thromboembolic events (VTE). Majority of such patients are treated in ambulatory settings where thromboprophylaxis is not routinely offered. In this study, we report on VTE rates and search for predictors that may help identify patients at higher risk to justify VTE-prophylaxis in ambulatory settings. Patients with pathologically-confirmed gastric adenocarcinoma were retrospectively reviewed for VTE detected by imaging studies. Clinical and pathological features known to increase the risk of VTE were studied. Khorana risk assessment model was applied on patients receiving chemotherapy. A total of 671 patients; median age 55 years, were recruited. VTE were diagnosed in 150 (22.4%) patients, including 42 (28.0%) pulmonary embolism and 18 (12.0%) upper extremity deep vein thrombosis (DVT). Majority (> 80%) developed VTE while in ambulatory settings and none had been on thromboprophylaxis. Rate was higher (27.1%) among 365 patients with metastatic compared to 16.7% among 306 patients with nonmetastatic disease, p = 0.001. Patients with metastatic disease who received multiple lines of chemotherapy (n = 85) had significantly higher rate of VTE compared to those who received a single line; 48.2% versus 19.4%, p
Databáze:	OpenAIRE
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