Early myocardial deformation changes in hypercholesterolemic and obese children and adolescents: a 2D and 3D speckle tracking echocardiography study
| Autor: | Francesco Martino, Eliana Martino, Massimo Vitarelli, Lidia Capotosto, Antonio Vitarelli, Serafino Ricci, Rasul Ashurov, Fabio Maramao, Cristina Zanoni, Ysabel Conde, Chiara Colantoni, Stefania De Chiara |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Percentile medicine.medical_specialty Adolescent Heart Ventricles Hypercholesterolemia 3D speckle tracking echocardiography Diastole Echocardiography Three-Dimensional Observational Study speckle tracking imaging Speckle tracking echocardiography Comorbidity Article myocardial deformation Body Mass Index left ventricular function chemistry.chemical_compound Internal medicine medicine Humans Obesity Child business.industry Cholesterol Myocardium dyslipidemia Case-control study General Medicine Cholesterol LDL medicine.disease chemistry Echocardiography echocardiography Case-Control Studies Cardiology Female business Body mass index Dyslipidemia |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Dyslipidemia and obesity are considered strong risk factors for premature atherosclerotic cardiovascular disease and increased morbidity and mortality and may have a negative impact on myocardial function. Our purpose was to assess the presence of early myocardial deformation abnormalities in dyslipidemic children free from other cardiovascular risk factors, using 2-dimensional speckle tracking echocardiography (2DSTE) and 3-dimensional speckle tracking echocardiography (3DSTE). We studied 80 consecutive nonselected patients (6–18 years of age) with hypercholesterolemia (low-density lipoprotein [LDL] cholesterol levels >95th percentile for age and sex). Forty of them had normal weight and 40 were obese (body mass index >95th percentile for age and sex). Forty healthy age-matched children were selected as controls. Left ventricular (LV) global longitudinal, circumferential, and radial strains were calculated by 2DSTE and 3DSTE. Global area strain (GAS) was calculated by 3DSTE as percentage of variation in surface area defined by the longitudinal and circumferential strain vectors. Right ventricular (RV) global and free-wall longitudinal strain and LV and RV diastolic strain rate parameters were obtained. Data analysis was performed offline. LV global longitudinal strain and GAS were lower in normal-weight and obese dyslipidemic children compared with normal controls and reduced in obese patients compared with normal-weight dyslipidemic children. LV early diastolic strain rate was lower compared with normals. RV global and free-wall longitudinal strain was significantly reduced in obese patients when compared with the control group. A significant inverse correlation was found between LV strain, LDL cholesterol levels, and body mass index. 2DSTE and 3DSTE show LV longitudinal strain and GAS changes in dyslipidemic children and adolescents free from other cardiovascular risk factors or structural cardiac abnormalities. Obesity causes an additive adverse effect on LV strain parameters and RV strain impairment. |
| Databáze: | OpenAIRE |
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