Increase in the isolation-induced social behavioural deficit by agonists at 5-HT1A receptors
| Autor: | Henriette Frances, Frederic Khidichian, Claire Monier |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Tetrahydronaphthalenes Stimulation Motor Activity Serotonergic Piperazines Buspirone Mice Cellular and Molecular Neuroscience Penbutolol Internal medicine medicine Animals Social Behavior Receptor 5-HT receptor Pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin Chemistry Ipsapirone Pyrimidines Endocrinology Anti-Anxiety Agents Social Isolation Receptors Serotonin Exploratory Behavior Serotonin medicine.drug |
| Zdroj: | Neuropharmacology. 29:103-107 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(90)90049-w |
| Popis: | The effect of 5-HT1A agonists was studied in the isolation-induced social behavioural deficit test. The drugs 8-OH-DPAT (0.125 mg/kg), buspirone (16 mg/kg) and ipsapirone (8 mg/kg) further increased the deficit. Unlike 8-OH-DPAT, the other two drugs may act non-specifically since they reduced spontaneous motor activity at 16 mg/kg, as measured in an activity meter. In addition, 8-OH-DPAT (0.25 mg/kg), buspirone (8 mg/kg) and ipsapirone (8 mg/kg) decreased exploratory activity in the open-field test. Since the smallest active doses were very close in the behavioural deficit and in the open-field tests, it is suggested that a common phenomenon, increased emotionality or reactivity, sustained both these reductions in activity. The increase in the behavioural deficit induced by 8-OH-DPAT, was likely to have resulted from stimulation of 5-HT1A receptors, since it was impaired by pretreatment with penbutolol, a beta-adrenergic-blocking drug, also known to bind to 5-HT1 receptors. Since it was previously shown that the behavioural deficit was reduced by agonists at 5-HT1B receptors, it is proposed that the behavioural inhibition, resulting from an isolation-induced increase in reactivity is bi-directionally modulated by serotonergic drugs, where 5-HT1A agonists increase and 5-HT1B agonists decrease this inhibition. |
| Databáze: | OpenAIRE |
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