Modulatory effect of voriconazole on the production of proinflammatory cytokines in experimental cryptococcosis in mice with severe combined immunodeficiency
| Autor: | C. Rodrigues Paula, L. da Silva Ruiz, E. Gonçalves da Silva, S. Marilia de Souza Silva, A. Latercia Tranches Dias |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antifungal Agents 030106 microbiology Pharmacology Proinflammatory cytokine 03 medical and health sciences Mice Amphotericin B medicine Animals Interleukin 6 Lung Cryptococcus neoformans Voriconazole Inflammation Severe combined immunodeficiency biology Lung Diseases Fungal business.industry Cryptococcosis medicine.disease biology.organism_classification Bioavailability Disease Models Animal 030104 developmental biology Infectious Diseases biology.protein Cytokines Drug Therapy Combination Severe Combined Immunodeficiency business medicine.drug |
| Zdroj: | Journal de mycologie medicale. 28(1) |
| ISSN: | 1773-0449 |
| Popis: | Summary Cryptococcosis is a subacute or chronic disease. For many years, amphotericin B has been used in severe fungal infections. Voriconazole is a triazole with high bioavailability, a large distribution volume, and excellent penetration of the central nervous system (CNS). The objective of this study was to evaluate the production of pro-inflammatory cytokines in the lungs during an experimental infection caused by C. neoformans in murine model (SCID) that was treated with amphotericin B and voriconazole. After intravenous inoculation with 3.0 × 105 viable yeast cells, the animals were treated with amphotericin B and voriconazole. The daily treatments began 24 hours after inoculation and lasted 15 days. We evaluated the survival curve and we measured the levels of TNF-α, IL-6 and IL-10. For all treatments, there was a significant increase in survival compared to the untreated group of animals and the group treated with voriconazole (maximum concentration). The levels of pro-inflammatory cytokines were significantly lower in the groups treated with voriconazole (maximum concentration) and amphotericin B (minimum concentration). Under the conditions studied, we can suggest by that the production of pro-inflammatory cytokines mediated by amphotericin B and voriconazole is dependent on the concentration administered. |
| Databáze: | OpenAIRE |
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