High Cytokine Levels in Tonsillitis Secretions Regardless of Presence of Beta-Hemolytic Streptococci
| Autor: | Kristian Roos, Susann Skovbjerg, Stig E. Holm, Agnes E. Wold, Annika Ljung, Sigvard Olofsson, Magnus Lindh, Ingegerd Adlerberth, Lars Hynsjö |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Adolescent medicine.medical_treatment Immunology Tonsillitis Inflammation Biology Dinoprostone Virus law.invention Interferon-gamma Young Adult law Virology medicine Humans Prostaglandin E2 Child Polymerase chain reaction Tumor Necrosis Factor-alpha Interleukins Streptococcus Interleukin Cell Biology Middle Aged medicine.disease Cytokine Child Preschool DNA Viral Cytokines Female Tumor necrosis factor alpha medicine.symptom medicine.drug |
| Zdroj: | Journal of Interferon & Cytokine Research. 35:682-689 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/jir.2014.0123 |
| Popis: | Acute pharyngotonsillitis denotes tonsillar inflammation caused by bacteria or viruses. Here, we investigated if beta-hemolytic streptococci (β-HS) tonsillitis would differ in inflammatory mediator response from tonsillitis of other causes. Tonsillar secretions were obtained from 36 acute pharyngotonsillitis patients and 16 controls. Bacteria were cultured quantitatively and 18 different viruses were quantified by real-time polymerase chain reaction. Cytokine and prostaglandin E2 (PGE2) levels were determined by enzyme-linked immunosorbent assays. Almost half of the patients' tonsillar secretions yielded high counts of β-HS, and most samples contained viruses, irrespective of whether β-HS were present or not. The Epstein-Barr virus (EBV) was the most common virus (patients 62% and controls 13%). Compared to controls, patients' secretions had higher levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF), and PGE2, while few samples contained IL-12, IL-10, or interferon-gamma (IFN-γ). The presence of β-HS in tonsillitis secretions could not be distinguished by any of the measured mediators, while the presence of EBV DNA tended to be associated with enhanced levels of IL-1β and IL-8. The results suggest a common inflammatory response in acute pharyngotonsillitis, regardless of causative agent. The suggested correlation between intense inflammation and the presence of EBV DNA in tonsillitis secretions may be due to reactivation of the virus and/or the EBV-containing B cells. |
| Databáze: | OpenAIRE |
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