A Newly Devised Formulation for Self-Medication Enhances Interferon-.GAMMA. Production and Proliferation of Splenic Lymphocytes
| Autor: | Ikuo Saiki, Tadato Tani, Atsushi Chino, Eiji Tega, Chizuru Kiga, Keiichi Koizumi, Hiroaki Sakurai |
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| Rok vydání: | 2005 |
| Předmět: |
Herbal Medicine
Pharmaceutical Science Spleen Immunoglobulin E Interferon-gamma Mice Th2 Cells In vivo Oral administration Immunity medicine Animals Interleukin 4 Pharmacology Mice Inbred BALB C biology business.industry General Medicine Th1 Cells In vitro medicine.anatomical_structure Concanavalin A Immunology biology.protein business |
| Zdroj: | Biological and Pharmaceutical Bulletin. 28:1869-1872 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.28.1869 |
| Popis: | A newly devised formulation for self-medication in Toyama, PanaWang, is a new herbal medicine (so called Toyama original brand formulation) developed based on traditional philosophy and scientific evidence. We here tried to examine the effect of oral administration of PanaWang on the balance of type I helper T cells (Th1) and Th2 cells. Splenic lymphocytes from normal mice were stimulated with Concanavalin A (Con A) in vitro and the secretion of Th1- and Th2-type cytokines, interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) respectively, was investigated. Con A-induced production of IFN-gamma from spleen cells, but not IL-4, was enhanced by the administration of PanaWang. Increased production of IFN-gamma was also detected in splenic lymphocytes from Th2-predominant BALB/c mice after DNP-immunization, without a change in antigen-specific IgE levels in vivo. Antigen-specific proliferative responses were also increased in lymphocytes from PanaWang-treated mice. These findings raise the possibility that PanaWang has Th1-stimulating activity and induces Th1-predominant immunity. |
| Databáze: | OpenAIRE |
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