The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol

Autor:	Geoffrey N. Woodruff, Kenneth A. Munday, C. Sumners, Judith A. Poat
Rok vydání:	1979
Předmět:	Male Fluphenazine Carbachol Chlorpromazine Dopamine Drinking Behavior Pharmacology Pimozide Haloperidol Animals Medicine Clozapine Injections Intraventricular business.industry Angiotensin II Rats Flupenthixol Sulpiride business Injections Intraperitoneal Antipsychotic Agents medicine.drug
Zdroj:	Psychopharmacology. 60:291-294
ISSN:	1432-2072 0033-3158
DOI:	10.1007/bf00426670
Popis:	The effect of a series of neuroleptic drugs on the drinking response elicited by intracerebroventricular injection of either angiotensin or carbachol into conscious rats was studied. The i.p. injection of haloperidol, cis-flupenthixol, or fluphenazine antagonized both angiotensin-induced and carbachol-induced drinking. When injected into the lateral ventricles, the neuroleptics haloperidol, fluphenazine, cis-fluphenthixol and sulpiride were potent inhibitors of angiotensin-induced drinking, but had little effect on the dipsogenic action of carbachol. Clozapine, administered centrally, antagonized drinking caused by both angiotensin and carbachol. Pimozide and chlorpromazine were also potent inhibitors of angiotensin-induced drinking, while trans-flupenthixol was inactive. Our results support the concept of an involvement of dopamine in angiotensin-induced drinking.
Databáze:	OpenAIRE
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