Study of selected birth defects among American Indian/Alaska Native population: A multi-state population-based retrospective study, 1999-2007
| Autor: | Tom Anderson, Del Yazzie, Robert E. Meyer, Russell S. Kirby, Mark A. Canfield, Julie Dunn, Sarah C. Fisher, Cara T. Mai, Glenn Copeland, Lisa Marengo, Timothy J. Flood, Mary K. Ethen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Embryology medicine.medical_specialty Health Toxicology and Mutagenesis Native population Population Population health 030105 genetics & heredity Toxicology White People Article Congenital Abnormalities 03 medical and health sciences 0302 clinical medicine Fetus Risk Factors medicine Ethnicity Prevalence Humans 030212 general & internal medicine education Retrospective Studies education.field_of_study Multi state business.industry Public health Microtia Infant Newborn Infant Retrospective cohort study medicine.disease Alaskan Natives United States Anotia Population Surveillance Pediatrics Perinatology and Child Health Epidemiological Monitoring Indians North American Female Public Health business Developmental Biology Demography |
| Zdroj: | Birth defects research. 110(19) |
| ISSN: | 2472-1727 |
| Popis: | Background Higher prevalence of selected birth defects has been reported among American Indian/Alaska Native (AI/AN) newborns. We examine whether known risk factors for birth defects explain the higher prevalence observed for selected birth defects among this population. Methods Data from 12 population-based birth defects surveillance systems, covering a birth population of 11 million from 1999 to 2007, were used to examine prevalence of birth defects that have previously been reported to have elevated prevalence among AI/ANs. Prevalence ratios (PRs) were calculated for non-Hispanic AI/ANs and any AI/ANs (regardless of Hispanic ethnicity), adjusting for maternal age, education, diabetes, and smoking, as well as type of case-finding ascertainment surveillance system. Results After adjustment, the birth prevalence of two of seven birth defects remained significantly elevated among AI/ANs compared to non-Hispanic whites (NHWs): anotia/microtia was almost threefold higher, and cleft lip +/- cleft palate was almost 70% higher compared to NHWs. Excluding AI/AN subjects who were also Hispanic had only a negligible impact on adjusted PRs. Conclusions Additional covariates accounted for some of the elevated birth defect prevalences among AI/ANs compared to NHWs. Exclusion of Hispanic ethnicity from the AI/AN category had little impact on birth defects prevalences in AI/ANs. NHWs serve as a viable comparison group for analysis. Birth defects among AI/ANs require additional scrutiny to identify modifiable risk and protective factors. |
| Databáze: | OpenAIRE |
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