Effect of Estradiol Benzoate on Lipid Metabolism in the Rat
| Autor: | Robert E. Pirrie, Mona E. Fewster, David A. Turner |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Phospholipid Acetates Fatty Acids Nonesterified Glycerides chemistry.chemical_compound Endocrinology Internal medicine Blood plasma medicine Animals Phospholipids Carbon Isotopes Chromatography Estradiol Cholesterol Myocardium Fatty Acids Reverse cholesterol transport Lipid metabolism Lipids Rats Liver chemistry Estrogen Estradiol benzoate lipids (amino acids peptides and proteins) Sodium acetate |
| Zdroj: | Endocrinology. 80:263-271 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-80-2-263 |
| Popis: | The effect of estradiol benzoate on the concentration of lipids in the plasma, liver and heart and on the incorporation of acetate 1-14C into lipids in these tissues has been studied in adult male rats. Following the daily injection of 1.7 mg of estradiol benzoate for 5 days, estrogen- treated and control animals were injected with 14 μc of sodium acetate 1-14C and killed 2, 4, 12, 24, 48 and 60 hr after the injection. There was a marked decrease in plasma free and esterified cholesterol, plasma phospholipids and the plasma cholesterol/phospholipid (C/P) ratio. The accompanying increase in liver cholesterol ester suggests that estradiol benzoate causes the transfer of cholesterol ester from the plasma to the liver. The increased turnover rate of plasma free cholesterol but lack of increase in liver free cholesterol may be due to an influx of free cholesterol from the plasma to the liver, the effect of which is balanced by a decreased rate of hepatic free cholesterol synthesis. There was a decreased incorp... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|