Assessment of Microvasculature After Intervention as a Predictor of Wound Healing in Patients With Tissue Loss
| Autor: | Kohei Azuma, Tatsuya Shiraki, Makoto Utsunomiya, Osamu Iida, Takumi Inoue, Hideaki Aihara, Masahiko Fujihara, Daizo Kawasaki, Kenichi Fujii, Yusuke Iwasaki, Masashi Fukunaga, Mitsuyoshi Takahara, Tsuyoshi Nakata, Yoshiaki Yokoi, Hiroyoshi Yokoi, Shinya Sasaki, Yoshinori Tsubakimoto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Critical Illness medicine.medical_treatment Diagnostic Techniques Cardiovascular 030204 cardiovascular system & hematology Balloon Microcirculation Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine Japan Ischemia Predictive Value of Tests Angioplasty medicine Clinical endpoint Humans Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Aged 80 and over Wound Healing business.industry Critical limb ischemia Surgery Peripheral Treatment Outcome Regional Blood Flow Female medicine.symptom Cardiology and Cardiovascular Medicine Wound healing business Angioplasty Balloon |
| Zdroj: | JACC: Cardiovascular Interventions. 13:976-985 |
| ISSN: | 1936-8798 |
| Popis: | This study investigated the correlation between vascular flow reserve (VFR) values and wound healing rate in patients with critical limb ischemia.Peripheral VFR may be useful for predicting complete wound healing after endovascular therapy (EVT). However, published reports included small numbers of patients from single centers and long-term outcomes remain unknown.This was a prospective multicenter study that consecutively enrolled 104 patients (115 limbs) who received EVT for ischemic ulcerations. All lesions were treated with conventional balloon angioplasty. After EVT, VFR was measured using a pressure/temperature guidewire. The study endpoints were correlation between VFR values and wound healing rate at 3 months and 1 year.The median VFR was 2.9. A total of 110 and 104 limbs completed the 3-month and 1-year follow-up, respectively. The 3-month and 1-year wound healing rates were 49% and 76%, respectively. VFR was significantly associated with the 3-month and 1-year wound healing (p 0.001 for both). The crude hazard ratios of VFR (per 2-fold increase) for the 3-month and 1-year wound healing were 2.6 (1.7 to 3.9) and 2.9 (2.0 to 4.2), respectively. The estimated median time to wound healing was 5.0 (3.2 to 7.2) months, 3.3 (2.8 to 4.9) months, and 2.5 (2.0 to 3.0) months, when the VFR value was 2.4, 2.9, and 3.9, respectively.Post-procedure VFR is significantly associated with wound healing. VFR, measured in the catheterization laboratory, is useful in clinical risk stratification for patients with critical limb ischemia after EVT. (Predictor of Wound Healing in Patients with Critical Limb Ischemia-Multicenter Prospective Study; UMIN000012746). |
| Databáze: | OpenAIRE |
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