Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland
| Autor: | Yuichiro Kuratomi, Kumiko Suzuki, Mikio Monji, Shinichi Aishima, Mitsuo Nakamura, Keita Kai, Hisayuki Tsugitomi, Akimichi Minesaki |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Histology Biopsy Fine-Needle Papanicolaou stain Class iii Salivary Glands Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Immunophenotyping medicine Humans medicine.diagnostic_test Salivary gland business.industry Mammary analogue secretory carcinoma General Medicine Benign lesion Middle Aged Salivary Gland Neoplasms Secretory Carcinoma 030104 developmental biology Fine-needle aspiration medicine.anatomical_structure 030220 oncology & carcinogenesis Mammary Analogue Secretory Carcinoma business |
| Zdroj: | Acta cytologica. 61(6) |
| ISSN: | 1938-2650 |
| Popis: | Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i.e., class II, III, and V). To investigate the potential for discrepant diagnosis of MASC on a larger scale, we distributed a survey with questions about the cytological diagnosis of the present case to cytologists at other institutions. A total of 109 cytologists completed the survey, providing varying assessments of the Papanicolaou classification: class I/II (14%), class III (53%), and class IV/V (33%). Most of the respondents (72%) could not identify a particular tumor or disease. Even the respondents who identified a particular tumor suggested widely differing diagnoses, from a benign lesion to various malignant tumors. Only 2 respondents correctly identified MASC. Conclusion: Our experience and the results of the survey suggest difficulty in the cytodiagnosis of MASC. |
| Databáze: | OpenAIRE |
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