Plasma orexin-A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition
| Autor: | Yasemin Ertaş, Feride Çelebi, Makbule Gezmen-Karadag, Onur Toka, Duygu Türközü, Hilal Yildiran, Banugül Barut Uyar, Gamze Akbulut, Nevin Sanlier, Nurdan Kokturk, Ozge Tugce Pasaoglu, Emine Yassibas |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
medicine.medical_specialty orexin-A chemistry.chemical_element Calcium chronic obstructive pulmonary disease Orexin-A Immunology and Microbiology (miscellaneous) Internal medicine mental disorders medicine In patient COPD business.industry digestive oral and skin physiology General Medicine Articles Anthropometry medicine.disease Endocrinology chemistry ghrelin Ghrelin Composition (visual arts) business diet Body mass index anthropometric measurements hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and Therapeutic Medicine |
| Popis: | Orexin-A and ghrelin are two important polypeptides that stimulate food intake, however, there is a lack of sufficient information concerning their plasma levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the association between plasma orexin-A and ghrelin levels with food consumption and body composition in patients with stable phase COPD. In total, 40 patients (age, 44-80 years; male, 31; female 9) who were in the stable phase of COPD were included in the study. Blood samples for plasma orexin-A and ghrelin analysis were collected after 8-12 h of fasting; certain anthropometric measurements were obtained and a 24-h dietary recall was recorded. The mean plasma orexin-A levels in the male and female patients were 1.3 +/- 0.37 and 1.4 +/- 0.13 ng/ml, respectively, while the mean plasma ghrelin levels were 25.9 +/- 7.31 and 27.3 +/- 8.54 ng/ml, respectively. No significant correlation was observed between the body mass index and plasma orexin-A and ghrelin levels or between the plasma ghrelin levels and dietary nutrient intake (P>0.05). The plasma orexin-A levels were demonstrated to be higher in patients with a higher dietary total fibre intake (r=0.303, P=0.022). A similar correlation was observed between plasma orexin-A levels and dietary intake of soluble (r=0.033, P=0.029) and insoluble (r=0.335, P=0.024) fibre, as well as between the daily consumption of calcium and the levels of plasma orexin-A (r=0.065, P=0.046). Therefore, the results of the present study indicated that a positive correlation existed between dietary nutrient intake and plasma orexin-A levels in patients with COPD. |
| Databáze: | OpenAIRE |
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