Advances of immune checkpoints in colorectal cancer treatment
| Autor: | Chuanxin Wang, Yuli Wang, Yidan Ren, Qinlian Jiao, Abakundana Nsenga Ariston Gabrie, Xiaoyan Liu, Lutao Du, Yunshan Wang, Qin Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Colorectal cancer T-Lymphocytes medicine.medical_treatment Programmed Cell Death 1 Receptor RM1-950 Targeted therapy 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Humans Immunologic Factors CTLA-4 Antigen Gastrointestinal cancer Pharmacology Chemotherapy business.industry Cancer General Medicine Immunotherapy medicine.disease Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Immune checkpoints Therapeutics. Pharmacology Colorectal Neoplasms business |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 123, Iss, Pp 109745-(2020) |
| ISSN: | 0753-3322 |
| Popis: | Colorectal cancer (CRC) is a malignant gastrointestinal cancer that seriously threatens human health. Its morbidity and mortality are in the forefront of tumors. Chemotherapy and radiotherapy play an important role in the treatment of CRC, which can improve the survival time and quality of life of patients, but the treatment progress is slow, and the treatment effect is not satisfactory. In recent years, immunotherapy has been a new direction in the field of colorectal cancer treatment after radiotherapy, chemotherapy and targeted therapy. Immune checkpoints play a vital role in the immunotherapy of cancer, and take part in the immune escape of cancer, which is closely related to the occurrence and development of cancer. This article reviews the research progress of immune checkpoints and their blockers in the field of CRC, in order to help better use of the immune system to treat cancer. |
| Databáze: | OpenAIRE |
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