Clinico-radiological profile and outcome of dengue patients with central nervous system manifestations: A case series in an Eastern India tertiary care hospital
| Autor: | KY Yashavantha Kumar, SK Rousan Jaman, Anirban Ghosal, Kaushik Sen, Nirendra Mohan Biswas, Souren Pal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty encephalitis Encephalopathy Dengue virus medicine.disease_cause Asymptomatic lcsh:RC321-571 030218 nuclear medicine & medical imaging Dengue fever 03 medical and health sciences 0302 clinical medicine Acute disseminated encephalomyelitis medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry business.industry General Neuroscience Meningoencephalitis meningitis meningoencephalitis medicine.disease dengue Immunology Original Article facial nerve Neurology (clinical) medicine.symptom meningoencephalomyelitis business Meningitis 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Journal of Neurosciences in Rural Practice Journal of Neurosciences in Rural Practice, Vol 7, Iss 01, Pp 114-124 (2016) |
| ISSN: | 0976-3155 0976-3147 |
| Popis: | Background and Objective: Dengue, an acute viral disease, transmitted by Aedes mosquitoes, has a variable clinical spectrum ranging from asymptomatic infection to life-threatening dengue hemorrhagic fever and dengue shock syndrome. However, neurological complications, in general, are unusual but have been observed more frequently in the recent past, and some studies highlighted varied neurological complications during the course of illness. Although dengue is classically considered a nonneurotropic virus, there is increasing evidence for dengue viral neurotropism. In this study, we have evaluated clinico-radiological profile and outcome of nine serologically confirmed dengue patients having varied manifestations of central nervous system (CNS) involvement. Materials and Methods: All the consecutive patients presented with neurological complications with positive serology for dengue infection (IgM positivity) in Department of Medicine, in a tertiary care hospital in Eastern India from August 2013 to October 2014 were included in the study. These patients were subjected to a detailed clinical evaluation, laboratory assessment including complete hemogram, coagulation profile, liver function test, serum electrolytes, and routine CSF (Cerebrospinal Fluid) study with the exclusion of other common neuroinvasive pathogens. Results: Out of 9 patients with neurological complications associated with confirmed dengue infection, 2 (22%) patients had dengue encephalopathy, 5 (56%) patients have dengue encephalitis, 1 (11%) patient had dengue meningitis, and 1 (11%) patient had postdengue immune-mediated CNS involvement. Conclusion: This case series reaffirms the occurrence of varied CNS manifestations in dengue virus infection and underlines the importance of inclusion of dengue in the differential diagnosis of acute encephalitis syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|