???Ecstasy??? intoxication: life-threatening manifestations and resuscitative measures in the intensive care setting
Autor: | Oded Szold, Valery Rudick, Avi A. Weinbroum, Ron Ben-Abraham |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male Artificial ventilation medicine.medical_specialty Adolescent Critical Care Multiple Organ Failure N-Methyl-3 4-methylenedioxyamphetamine Resuscitation medicine.medical_treatment Ecstasy Seizures Intensive care medicine Humans Coma Israel Intensive care medicine Retrospective Studies medicine.diagnostic_test Illicit Drugs business.industry Lumbar puncture Metabolic acidosis Retrospective cohort study medicine.disease Treatment Outcome Hallucinogens Emergency Medicine Female Hyponatremia business Rhabdomyolysis |
Zdroj: | European Journal of Emergency Medicine. 10:309-313 |
ISSN: | 0969-9546 |
DOI: | 10.1097/00063110-200312000-00013 |
Popis: | OBJECTIVE The ingestion of 3,4-methylenedioxymethamphetamine ('ecstasy') can cause severe neurological impairment and multi-system damage. We describe the potentially life-threatening clinical features and the management of intoxication by this psychedelic drug in patients transferred from emergency services to the intensive care area. METHODS We conducted a retrospective analysis of 'ecstasy'-intoxicated patients admitted to a municipal hospital during a three-month period. RESULTS Of the 32 patients brought to the emergency services, three (9.3%; mean age 21+/-2 years) were transferred to the intensive care area in a comatose state associated with seizures after ingesting one to three tablets of 150 mg 3,4-methylenedioxymethamphetamine. All required artificial ventilation and none responded to painful stimuli. The brain computed tomography scan and lumbar puncture results were normal. The main clinical manifestations were hyponatremia, high fever, rhabdomyolysis, dehydration and metabolic acidosis accompanied by impaired liver and renal functions. All three patients regained consciousness after 2.1+/-0.8 days of system-oriented supportive care and were discharged for further surveillance in medical wards after 4.3+/-2.1 days. CONCLUSION The increase in life-threatening episodes of 3,4-methylenedioxymethamphetamine intoxication that mandate admission, treatment and close surveillance in an intensive care milieu make it incumbent to establish appropriate management protocols for minimizing immediate mortality and late morbidity. |
Databáze: | OpenAIRE |
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