The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake
| Autor: | Lukas J. Volz, Christian Nelles, Marc Tittgemeyer, Esther Annegret Pelzer, John-Stuart Brittain, David J. Pedrosa, Peter Brown, Lars Timmermann |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Cerebellum Alcohol Drinking Essential Tremor Electroencephalography Article 03 medical and health sciences 0302 clinical medicine Rhythm Developmental Neuroscience Reaction Time medicine Humans Aged Tremor amplitude Cerebral Cortex Ethanol Essential tremor Supplementary motor area medicine.diagnostic_test Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Neurology Female Alcohol intake Nerve Net Psychology Neuroscience Photic Stimulation Psychomotor Performance 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Experimental Neurology. 297:50-61 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2017.07.013 |
| Popis: | The dysregulation of endogenous rhythms within brain networks have been implicated in a broad range of motor and non-motor pathologies. Essential tremor (ET), classically the purview of a single aberrant pacemaker, has recently become associated with network-level dysfunction across multiple brain regions. Specifically, it has been suggested that motor cortex constitutes an important node in a tremor-generating network involving the cerebellum. Yet the mechanisms by which these regions relate to tremor remain a matter of considerable debate. We sought to discriminate the contributions of cerebral and cerebellar dysregulation by combining high-density electroencephalography with subject-specific structural MRI. For that, we contrasted ET with voluntary (mimicked) tremor before and after ingestion of alcohol to regulate the tremorgenic networks. Our results demonstrate distinct loci of cortical tremor coherence, most pronounced over the sensorimotor cortices in healthy controls, but more frontal motor areas in ET-patients consistent with a heightened involvement of the supplementary motor area. We further demonstrate that the reduction in tremor amplitude associated with alcohol intake is reflected in altered cerebellar - but not cerebral - coupling with movement. Taken together, these findings implicate tremor emergence as principally associated with increases in activity within frontal motor regions, whereas modulation of the amplitude of established tremor relates to changes in cerebellar activity. These findings progress a mechanistic understanding of ET and implicate network-level vulnerabilities in the rhythmic nature of communication throughout the brain. |
| Databáze: | OpenAIRE |
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