Estrogen receptors (ERα/ERβ) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma
| Autor: | M. C. Vacher-Lavenu, Jean-claude Honoré, Thérèse-Marie Mignot, Marie-Josèphe Leroy, C. Benassayag, C. Chapron, Françoise Ferré, Brigitte Robert, Virginie Rigourd |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Physiology medicine.drug_class Endocrinology Diabetes and Metabolism Uterus Estrogen receptor Biology Pregnancy Reference Values Physiology (medical) Internal medicine Gene expression medicine Humans RNA Messenger Receptor Leiomyoma Myometrium musculoskeletal system medicine.disease female genital diseases and pregnancy complications Kinetics Endocrinology medicine.anatomical_structure Receptors Estrogen In utero Estrogen Uterine Neoplasms Female |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1999.276.6.e1112 |
| Popis: | The distributions of the mRNAs for estrogen receptors (ERalpha and ERbeta) and their binding properties in myometria of pregnant and nonpregnant women and in leiomyoma were studied. RT-PCR analysis indicated that the term pregnancy myometria had little ERalpha mRNA, whereas the amounts of ERbeta mRNAs in pregnant or nonpregnant myometria appeared to be similar. Both ERalpha and ERbeta mRNA were greater in certain leiomyoma than in normal nonpregnant myometria. The binding kinetics revealed that two specific binding sites (with high or low affinity) for 17beta-estradiol were present in the nonpregnant myometrium. Only the low-affinity binding sites were detectable in late-pregnancy myometria and in leiomyoma, and their capacities were increased two- to threefold (P0.001) in leiomyoma. The pregnancy- and leiomyoma-related changes in myometrial ER status, especially the low concentration of ERalpha mRNA and the lack of high-affinity ER in pregnant women, plus the increased ERalpha and ERbeta mRNAs and the increased low-affinity ER in some leiomyoma, suggest that the redistribution of ER subtypes is associated with the pathological and/or normal growth of the myometrium. |
| Databáze: | OpenAIRE |
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