Widespread idiopathic pyoderma gangrenosum evolved from ulcerative to vegetative type: a 10-year history with a recent response to infliximab
| Autor: | Elvio Alessi, Athanasia Tourlaki, Ruggero Caputo, Angelo V. Marzano |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Necrosis medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Dermatology Monoclonal antibody Autoimmune Diseases Drug Resistance Bacterial Skin Ulcer medicine Humans business.industry Autoantibody Antibodies Monoclonal Ciclosporin medicine.disease Infliximab Pyoderma Gangrenosum Treatment Outcome Cytokine Neutrophilic dermatosis Immunology medicine.symptom business Pyoderma gangrenosum medicine.drug |
| Zdroj: | Clinical and Experimental Dermatology. 33:156-159 |
| ISSN: | 1365-2230 0307-6938 |
| DOI: | 10.1111/j.1365-2230.2007.02607.x |
| Popis: | Summary Pyoderma gangrenosum (PG) is an infrequent neutrophilic dermatosis, which commonly presents with a limited number of ulcerative, pustular, bullous or vegetative lesions associated with an underlying systemic disorder. We report a 34-year-old man with ulcerative PG that was exceptionally widespread and not associated with any other condition. Moreover, it was resistant to steroid treatment and, after prolonged use of ciclosporin, it unexpectedly developed a vegetative pattern, further supporting the hypothesis that the different forms of PG are part of a single clinical spectrum. Finally, dramatic improvement of the condition occurred after treatment with infliximab, an antitumour necrosis factor-α monoclonal antibody; however, this produced circulating autoantibodies. Although this has not had any clinical consequence to date, accurate follow-up in patients treated with infliximab is essential to monitor the onset of a possible autoimmune disorder induced by the drug. |
| Databáze: | OpenAIRE |
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