JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment
| Autor: | Luis Arturo Fonseca-Fonseca, Diogo O. Souza, Nelson Merino García, Odalys Valdés Martínez, Abel Mondelo-Rodriguez, Roberto Menéndez Soto del Valle, Guillermo Aparicio Lopez, Yanay Montano-Peguero, Jeney Ramírez-Sánchez, Javier Jiménez-Martin, Gilberto L. Pardo-Andreu, Alejandro Saúl Padrón-Yaquis, João Rocha, Adriano Martimbianco de Assis, Maylin Wong-Guerra, Fernanda D Avila, Yanier Nuñez-Figueredo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Scopolamine Hippocampus Pharmacology Hippocampal formation medicine.disease_cause Neuroprotection Niacin Antioxidants 03 medical and health sciences Benzodiazepines Random Allocation 0302 clinical medicine Memory Medicine Memory impairment Animals Cognitive Dysfunction Rats Wistar Prefrontal cortex Nootropic Agents Memory Disorders Dose-Response Relationship Drug business.industry Neurodegeneration Brain General Medicine medicine.disease Mitochondria Disease Models Animal 030104 developmental biology Neurology Acetylcholinesterase Cholinergic Neurology (clinical) Cholinesterase Inhibitors Lipid Peroxidation business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Neurological research. 41(5) |
| ISSN: | 1743-1328 |
| Popis: | Objective: JM-20, a novel hybrid synthetic molecule, has been reported to have antioxidant, mitoprotective, anti-excitotoxic, anti-apoptotic and anti-inflammatory properties. However, the neuroprotective effect of JM-20 against memory impairment in preclinical AD-like models has not been analyzed. The aim of this study was to evaluate the potential neuroprotection of JM-20 that preserves essential memory process from cholinergic dysfunction and other molecular damages. Methods: The effects of JM-20 on scopolamine (1 mg/kg)-induced cognitive disorders were studied. Male Wistar rats (220-230 g) were treated with JM-20 and/or scopolamine, and behavioral tasks were performed. The AChE activity, superoxide dismutase activity, catalase activity, MDA and T-SH level on brain tissue were determined by spectrophotometric methods. Mitochondrial functionality parameters were measured after behavioral tests. Histological analyses on hippocampus and prefrontal cortex were processed with hematoxylin and eosin, and neuronal and axonal damage were determined. Results: The behavioral, biochemical and histopathological studies revealed that oral pre-treatment with JM-20 (8 mg/kg) significantly attenuated the scopolamine-induced memory deficits, mitochondrial malfunction, oxidative stress, and prevented AChE hyperactivity probably due to specific inhibition of AChE enzyme. It was also observed marked histological protection on hippocampal and prefrontal-cortex regions. Conclusions: The multimodal action of this molecule could mediate the memory protection here observed and suggest that it may modulate different pathological aspects of memory de?cits associated with AD in humans. |
| Databáze: | OpenAIRE |
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