Coplanar PCBs in human milk in the province of Québec, Canada: are they more toxic than dioxin for breast fed infants?
| Autor: | Claire Laliberté, Eric Dewailly, Suzanne Gingras, Jean Philippe Weber |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Health Toxicology and Mutagenesis Population Toxic potential Breast milk Toxicology Dioxins Age groups Biomonitoring Ecotoxicology Humans education Prenatal exposure Benzofurans education.field_of_study Milk Human Chemistry Infant Newborn Quebec food and beverages General Medicine Pollution Lipids Polychlorinated Biphenyls Biological materials Environmental chemistry Female |
| Zdroj: | Bulletin of environmental contamination and toxicology. 47(4) |
| ISSN: | 0007-4861 |
| Popis: | Different experimental studies have increased our understanding of toxic mechanisms of PCBs, PCDDs and PCDFs. Recently, coplanar PCBs which are approximate stereoisomers of 2,3,7,8-TCDD have been found to be the most toxic congeners of PCBs with a toxicity relative to that of 2,3,7,8 TCDD ranging from 0.001 for mono-ortho coplanars to 0.01, 0.1 and 0.05 respectively for tetra, penta and hexa non-ortho coplanar congeners. These congeners are present in different biological specimens at very high levels when compared with levels of TCDD. Therefore, coplanar PCBs determination is useful in evaluating the toxic potential of breast milk for infants. Moreover, the assessment of the relative importance of these compounds compared with other PCB congeners and PCDDs/PCDFs could be helpful in choosing the most suitable toxic parameters for the biomonitoring of human populations. This paper presents and discusses the levels of coplanar PCBs in the breast milk of a representative sample of 96 women from the general population of the province of Quebec - Canada. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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