Aspirin reduces anticardiolipin antibodies in patients with coronary artery disease
| Autor: | Petros Nihoyannopoulos, Georgia Vamvakou, John Lekakis, F. Andreotti, Sozos Loizou, I. Revela, Ignatios Ikonomidis, D Th Kremastinos |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Analgesic Coronary Artery Disease Placebo Biochemistry Gastroenterology Coronary artery disease Double-Blind Method Internal medicine medicine Humans cardiovascular diseases Antipyretic Aspirin Cross-Over Studies business.industry Anti-Inflammatory Agents Non-Steroidal Case-control study General Medicine Middle Aged medicine.disease Crossover study Surgery medicine.anatomical_structure Antibodies Anticardiolipin Case-Control Studies Female business Artery medicine.drug |
| Zdroj: | European journal of clinical investigation. 36(12) |
| ISSN: | 0014-2972 |
| Popis: | Background Anticardiolipin antibodies (aCL) have been found to be elevated in patients with coronary artery disease (CAD) and have been associated with an adverse outcome owing to their prothrombotic activity. The aim of this study was to investigate the effect of aspirin treatment on aCL levels in patients with chronic CAD. Materials and methods Forty patients with chronic CAD scheduled for elective coronary artery bypass graft surgery (CABG) and 40 healthy controls participated in the study. Patients were treated with 300 mg of aspirin once daily (o.d.) for the first 12 days and placebo for the following 12 days before CABG in a double-blind, cross-over trial. Immunoglobulin (Ig) G-, IgM-, IgA-aCL and C-reactive protein (CRP) levels were measured in the controls and at the end of each treatment period in the patients with CAD. Results The IgA- and IgG-aCL levels were greater in patients with CAD than in the controls. Compared with the placebo, IgA, IgG subtypes and CRP levels were reduced after aspirin treatment (P = 0·001, P = 0·02, P = 0·04, respectively). The percentage reduction of IgA- and IgG-aCL was related to the percentage reduction of CRP after aspirin (P |
| Databáze: | OpenAIRE |
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