Gamma-treated placental amniotic membrane allograft as the adjuvant treatment of unresponsive diabetic ulcer of the foot
| Autor: | Ihsan Oesman, Witantra Dhamar Hutami |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chronic wound
medicine.medical_specialty medicine.medical_treatment Cell Diabetic ulcer of the foot Inflammation Article 03 medical and health sciences 0302 clinical medicine Allograft Diabetes mellitus Medicine Secretion Case series Debridement business.industry medicine.disease digestive system diseases Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Placental amniotic membrane 030211 gastroenterology & hepatology Cytokine secretion medicine.symptom business Wound healing |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| DOI: | 10.1016/j.ijscr.2019.12.033 |
| Popis: | Highlights • Unresponsive diabetic ulcer is ulcer that does not reduce in size within a month. • It is caused by senescent cells, absence of growth factors, and other cellular abnormalities. • To maximize wound healing, skin substitute can be used to prevent infection and dessication. • Amniotic membrane favoured healing of unresponsive and non-healing ulcers. Introduction Diabetic ulcer of the foot is a major cause of morbidity and is a leading cause of hospitalization in patients with diabetes, and causes productivity and financial losses that lower the quality of life of the patient. The wound is categorized as responsive and unresponsive wound, which occurs in debilitated patients as seen in diabetes mellitus. The delay in wound repair can be caused by senescent cells, absence of growth factors, and other cellular abnormalities. Method This is a retrospective, single-centre case series with non-consecutive cases. Patients with diabetic ulcer of the foot managed using gamma-treated placental amniotic membrane, with the minimum follow up of 1 month in academic practice setting were recruited. Result Three patients with 4 weeks period of oozing ulcers and signs of inflammation were included in this case series. Two layers of amniotic membrane dressing was applied weekly after cleaning and debridement for 3 weeks. Wound size and secretion were documented by taking photographs every week. At the end of the third week, the wound healed. Discussion Placental amniotic membranes are composed of cells, extra-cellular matrix (ECM), and a complex of regulatory cytokines which promote cell proliferation, cell modulation, and cytokine secretion by variety of cell types involved in wound healing. Our study showed that the treatment of diabetic ulcer wound using amniotic membrane was successful in achieving wound healing in unresponsive, chronic wound of diabetic ulcer of the foot. Conclusion Our results clearly indicated the usefulness of the application of amniotic membranes in treatment of diabetic ulcer of the foot. Amniotic membrane favoured healing of unresponsive and non-healing ulcers. |
| Databáze: | OpenAIRE |
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