Albumin-Folate Conjugates for Drug-targeting in Photodynamic Therapy
| Autor: | Kathrin Butzbach, M. Micaela Gonzalez, Franco M. Cabrerizo, Federico A. O. Rasse-Suriani, Bernd Epe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell Survival medicine.medical_treatment Serum albumin Photodynamic therapy 010402 general chemistry 01 natural sciences Biochemistry Cell Line 03 medical and health sciences Folic Acid medicine Humans Folate Receptor 1 Physical and Theoretical Chemistry Cytotoxicity Albumin conjugates Photosensitizing Agents biology Chemistry Otras Ciencias Químicas Ciencias Químicas Serum Albumin Bovine General Medicine 0104 chemical sciences B-carbolines 030104 developmental biology Targeted drug delivery Photochemotherapy Drug delivery biology.protein Folate receptor 1 Photosensitization Phototoxicity CIENCIAS NATURALES Y EXACTAS Conjugate Carbolines |
| Zdroj: | Photochemistry and photobiology. 92(4) |
| ISSN: | 1751-1097 |
| Popis: | Photodynamic therapy (PDT) is based on the cytotoxicity of photosensitizers in the presence of light. Increased selectivity and effectivity of the treatment is expected if a specific uptake of the photosensitizers into the target cells, often tumor cells, can be achieved. An attractive transporter for that purpose is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe the synthesis and photobiological characterization of polar β-carboline derivatives as photosensitizers covalently linked to folate-tagged albumin as the carrier system. The particles were taken up by KB (human carcinoma) cells within |
| Databáze: | OpenAIRE |
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