Feasibility of autologous fibrin glue in general thoracic surgery

Autor:	Tadasu Kohno, Shigeyoshi Makino, Ryuichi Yoshimura, Sakashi Fujimori, Souichiro Suzuki, Akira Kohno, Naoko Kimura, Mitsuaki Kawashima, Shinji Yuhara, Makoto Wakatabe
Rok vydání:	2020
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty General thoracic surgery biology business.industry Pulmonary Surgical Procedures Fibrin Tissue Adhesive Perioperative Fibrin Surgery Cardiothoracic surgery medicine biology.protein Original Article Lung surgery business Fibrin glue
Zdroj:	Journal of Thoracic Disease. 12:484-492
ISSN:	2077-6624 2072-1439
DOI:	10.21037/jtd.2020.01.01
Popis:	Background Fibrin glue effectively controls air leakage in lung surgery; however, allogenic fibrin glue cannot eliminate the risks of infection and allergy despite current sterilization methods. Autologous fibrin glue (AFG) could be a good alternative, but is not commonly used worldwide because of its limited availability and lack of evidence. Herein, we report clinical outcomes of AFG in thoracic surgery. Methods We retrospectively analyzed patients who underwent lobectomies or segmentectomies between November 2016 and September 2017 in our institution. We used two types of AFGs. One was a partially-autologous fibrin glue (PAFG), the components of which are largely autologous but which contains allogenic thrombin. The other was a completely-autologous fibrin glue (CAFG) which has no allogenic components. PAFG was used in the first half of the study period, after which CAFG was used from March 2017 onward. Patients who did not undergo AFG generation were categorized as the non-AFG group. The perioperative outcomes of the three groups were evaluated. Results A total of 207 patients underwent lung surgery, including 118 lobectomies and 89 segmentectomies. Among them, 83 patients received PAFG, 94 received CAFG, and 30 received non-AFG. The mean postoperative drainage period was within a few days in each group (PAFG vs. CAFG vs. non-AFG: 3.23±3.91 vs. 3.16±4.04 vs. 3.17±4.16 days, respectively; P=0.405), and the incidence of postoperative prolonged air leakage was within an acceptable range (PAFG vs. CAFG vs. non-AFG: 13.3% vs. 12.8% vs. 16.7%, respectively; P=0.821). Conclusions The use of AFG is clinically feasible for patients who undergo lobectomies or segmentectomies. AFGs could be a viable alternative to conventional allogenic fibrin glues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e313d6bd28aeca2ac37f4cc62372dae https://doi.org/10.21037/jtd.2020.01.01 Zobrazit plný text záznamu