Distribution of human umbilical cord blood-derived mesenchymal stem cells in the Alzheimer's disease transgenic mouse after a single intravenous injection
| Autor: | Hyeri Hwang, Brian Hyung, Jeong Min Lee, Jung Won Hwang, Na Kyung Lee, Duk L. Na, Sang Eon Park, Soo Jin Choi, Jong Wook Chang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Pathology medicine.medical_specialty Transplantation Heterologous Vascular permeability Amyloidogenic Proteins Mice Transgenic Blood–brain barrier Mesenchymal Stem Cell Transplantation Umbilical cord Capillary Permeability 03 medical and health sciences SOX2 Alzheimer Disease medicine Presenilin-1 Animals Humans Neprilysin Lung business.industry General Neuroscience Myocardium SOXB1 Transcription Factors Mesenchymal stem cell Mesenchymal Stem Cells medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Liver Blood-Brain Barrier Immunology Injections Intravenous Alzheimer's disease business |
| Zdroj: | Neuroreport. 27(4) |
| ISSN: | 1473-558X |
| Popis: | The aim of this study was to track the migration of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered through a single intravenous injection and to observe the consequential therapeutic effects in a transgenic Alzheimer's disease mouse model. Ten-month-old APP/PS1 mice received a total injection of 1×10 cells through the lateral tail vein and were killed 1, 4, and 7 days after administration. On the basis of immunohistochemical analysis, hUCB-MSCs were not detected in the brain at any of the time points. Instead, most of the injected mesenchymal stem cells were found to be distributed in the lung, heart, and liver. In terms of the molecular effects, statistically significant differences in the amyloid β protein, neprilysin, and SOX2 levels were not observed among the groups. On the basis of the results from this study, we suggest that single intravenously administered hUCB-MSCs are not delivered to the brain and also do not have a significant influence on Alzheimer's disease pathology. |
| Databáze: | OpenAIRE |
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