Facile access to [1,2]-oxazine derivatives via annulations of aminoxy-tethered 1,7-enynes

Autor:	Raji Reddy Chada, Siddique Z. Mohammed, Kamalkishor Warudikar, Nagender Punna, Roshan Chandrakant Kajare, Mayur C. Bhandari, Mahender Khatravath
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Cyclopentenone chemistry.chemical_compound Ring-closing metathesis chemistry Organic Chemistry Oxazines Physical and Theoretical Chemistry Biochemistry Medicinal chemistry
Zdroj:	Organic & Biomolecular Chemistry. 19:809-821
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob02279a
Popis:	An efficient approach for the highly diastereoselective construction of functionalized cyclopenta[d][1,2]oxazines via sequential oxyamination and Pauson-Khand reaction of readily accessible propargylic alcohols has been developed. Furthermore, the ring closing metathesis of these N-O linked 1,7-enynes afforded vinylated-[1,2]oxazines in good yields. The reduction of the N-O bond of the obtained cyclopenta[d][1,2]oxazine is accomplished to access cyclopentenone-based amino alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e29ac5d6ed3996d69d28281dfeec897 https://doi.org/10.1039/d0ob02279a Zobrazit plný text záznamu