A single-center 10-year retrospective study of clinical features and surgical treatment of spinal metastasis from cholangiocarcinoma
| Autor: | Tong Niu, Yong Liu, Xi Zhou, Yipeng Wang, Shuzhong Liu, Muchuan Wang, Chengao Gao, Ziquan Li, Siyuan Yao, Zhen Huo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Disease Single Center Cholangiocarcinoma Percutaneous vertebroplasty 03 medical and health sciences 0302 clinical medicine Quality of life medicine Humans Medical history Surgical treatment Aged Retrospective Studies Advanced and Specialized Nursing Spinal Neoplasms business.industry Retrospective cohort study Middle Aged Prognosis Surgery Treatment Outcome Anesthesiology and Pain Medicine 030220 oncology & carcinogenesis Quality of Life Female business Spinal metastases 030217 neurology & neurosurgery |
| Zdroj: | Annals of Palliative Medicine. 10:1825-1833 |
| ISSN: | 2224-5839 2224-5820 |
| DOI: | 10.21037/apm-20-1576 |
| Popis: | Background This study intends to discuss the clinical features, therapeutic strategies, and patients' prognostic features and to share our expertise in handling this entity. Current research is one of Asia's extensive MSCCA clinical studies until now. Methods Four MSCCA patients who were operated in our hospital's bone tumor center from January 2010 to January 2020 were chosen. Our team reviewed a retrospective study of the medical history and records of surgery, imaging data, and pathology reports (both primary and metastatic spinal tumors) of all MSCCA patients. We applied two surgical therapies in this study, including open surgery and percutaneous vertebroplasty. A predetermined analysis of patients' original clinical data was performed, and regular followup was performed after the operation. Results Of the four patients, one was male and three were female. The age ranged from 60 to 70 years. The time duration between the diagnosis of cholangiocarcinoma (CCA) and the diagnosis of spinal metastases ranged from 0 to 11 months. Spinal metastatic disease was mainly located in the thoracic spine (n=4; 100%), followed by the cervical spine (n=1; 25.0%). Postoperatively, in the four patients, the symptoms improved and the VAS score was decreased. During the follow-up visit, the progression of the local spinal tumors at the site of primary spinal surgery was detected in three patients (75.0%). Three patients died from the disease during the follow-up period, and one patient is still alive. The time ranged from 6 to 13 months for spinal surgery to the patient's death. Conclusions Taken together, the prognosis of patients with MSCCA is poor. Surgical treatment can dramatically improve patients' quality of life and helps to extend a patient's survival. In terms of surgical treatment, appropriate surgical treatment should be selected according to the general condition of the patient and the relevant characteristics of spinal metastases. |
| Databáze: | OpenAIRE |
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