Childhood epidermal necrolysis and erythema multiforme major: a multicentre French cohort study of 62 patients
| Autor: | F. Boralevi, C. Bernier, Saskia Ingen-Housz-Oro, B. Bensaid, Stéphanie Leclerc-Mercier, C. Bodemer, Nadège Cordel, F. Tétart, A. Welfringer-Morin, M. Tauber, A.-M. Roguedas-Contios, L. Giraud-Kerleroux, N. Bellon, C. Fargeas, S. Renolleau, A. Brun, A. Du Thanh, B. Milpied, I. Costedoat, J. Coquin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Mycoplasma pneumoniae Adolescent Dermatology medicine.disease_cause Cohort Studies stomatognathic system Epidermal necrolysis Epidemiology otorhinolaryngologic diseases Humans Medicine Child Retrospective Studies Erythema Multiforme Body surface area business.industry Overlap syndrome medicine.disease Toxic epidermal necrolysis Erythema multiforme major stomatognathic diseases Infectious Diseases Child Preschool Stevens-Johnson Syndrome business Cohort study |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 35:2051-2058 |
| ISSN: | 1468-3083 0926-9959 |
| DOI: | 10.1111/jdv.17469 |
| Popis: | INTRODUCTION The distinction between epidermal necrolysis [EN; including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and overlap syndrome] and erythema multiforme major (EMM) in children is confusing. We aimed to better describe and compare these entities. MATERIALS AND METHODS This French retrospective multicentre study included children ≤18 years old referred for EN or EMM between 1 January 2008 and 1 March 2019. According to pictures, children were reclassified into TEN/overlap, SJS or EMM/unclassified (SJS/EMM) groups and compared for epidemiological and clinical data, triggers, histology and follow-up. RESULTS We included 62 children [43 boys, median age 10 years (range 3-18)]: 16 with TEN/overlap, 11 SJS and 35 EMM. The main aetiologies were drugs in EN and infections (especially Mycoplasma pneumoniae) in EMM (P |
| Databáze: | OpenAIRE |
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