An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals
| Autor: | Masanori Nakagawa, Ayaka Kimura, Takayuki Kondo, Soichiro Numa, Takashi Kasai, Tomoyuki Ohara, Yukie Kushimura, Toshiki Mizuno, Akihiro Tanaka, Kanako Morita, Hisashi Takahashi, Yu-ichi Noto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Optic Neuritis Prednisolone Anti-Inflammatory Agents Myelin oligodendrocyte glycoprotein Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Internal Medicine medicine Humans Optic neuritis Autoantibodies biology business.industry Multiple sclerosis Encephalomyelitis Acute Disseminated Autoantibody General Medicine medicine.disease Magnetic Resonance Imaging Oligodendrocyte Treatment Outcome 030104 developmental biology medicine.anatomical_structure Acute disseminated encephalomyelitis Immunology biology.protein Female Myelin-Oligodendrocyte Glycoprotein Antibody business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Internal Medicine. 55:699-702 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.55.5727 |
| Popis: | Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|