Low tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass heart surgery (MECANO): study protocol for a randomized controlled trial

Autor: Jean-Michel Grinda, Jean-Dominique Law Koune, Lee S. Nguyen, Hadrien Gibert, Alain Brusset, Pierre Squara, Philippe Estagnasie, Thierry Waldmann, Stephane Aubert, Messaouda Merzoug
Rok vydání: 2017
Předmět:
Lung Diseases
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Medicine (miscellaneous)
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
Study Protocol
0302 clinical medicine
Clinical Protocols
Double-Blind Method
law
Risk Factors
Fraction of inspired oxygen
medicine
Cardiopulmonary bypass
Tidal Volume
Humans
Pharmacology (medical)
Hospital Mortality
Cardiac Surgical Procedures
Hospital Costs
Lung
Tidal volume
Mechanical ventilation
lcsh:R5-920
Cardiopulmonary Bypass
Postoperative pulmonary complications
business.industry
Low tidal volume
Length of Stay
medicine.disease
Respiration
Artificial
Surgery
Cardiac surgery
Treatment Outcome
030228 respiratory system
Pneumothorax
Respiratory failure
Research Design
Ventilation (architecture)
France
lcsh:Medicine (General)
business
Protective ventilation
Zdroj: Trials
Trials, Vol 18, Iss 1, Pp 1-6 (2017)
ISSN: 1745-6215
0309-8524
Popis: Background Postoperative pulmonary complications are a leading cause of morbidity and mortality after cardiac surgery. There are no recommendations on mechanical ventilation associated with cardiopulmonary bypass (CPB) during surgery and anesthesiologists perform either no ventilation (noV) at all during CPB or maintain low tidal volume (LTV) ventilation. Indirect evidence points towards better pulmonary outcomes when LTV is performed but no large-scale prospective trial has yet been published in cardiac surgery. Design The MECANO trial is a single-center, double-blind, randomized, controlled trial comparing two mechanical ventilation strategies, noV and LTV, during cardiac surgery with CPB. In total, 1500 patients are expected to be included, without any restrictions. They will be randomized between noV and LTV on a 1:1 ratio. The noV group will receive no ventilation during CPB. The LTV group will receive 5 breaths/minute with a tidal volume of 3 mL/kg and positive end-expiratory pressure of 5 cmH2O. The primary endpoint will be a composite of all-cause mortality, early respiratory failure defined as a ratio of partial pressure of oxygen/fraction of inspired oxygen
Databáze: OpenAIRE
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