Inflammatory and Oxidative Stress Markers as Indicator of Atherogenesis in Rats: Antioxidants as Preventive Pharmacological Methods
| Autor: | Carla Buonanotte, María del Carmen Baez, Mónica Moya, Sergio Blencio, Ariel Balceda, Ismael Bernardo Fonseca, María de La Paz Scribano, Mariana Tarán |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment alpha-Tocopherol Immunology Aorta Thoracic Hyperfibrinogenemia Ascorbic Acid Oxidative phosphorylation Nitric Oxide Fibrinogen medicine.disease_cause Antioxidants Proinflammatory cytokine Superoxide dismutase Internal medicine medicine Animals Immunology and Allergy Rats Wistar Pharmacology biology Vitamin C Superoxide Dismutase Chemistry Vitamin E General Medicine Atherosclerosis Oxidative Stress Endocrinology biology.protein Endothelium Vascular Biomarkers Oxidative stress medicine.drug |
| Zdroj: | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 16 |
| ISSN: | 1871-5230 |
| DOI: | 10.2174/1871523016666170616121133 |
| Popis: | OBJECTIVE The oxidative process in atherogenesis generated by proinflammatory induction and response to antioxidants vitamins in an experimental model were analyzed. METHODS Male rats were used: (A)Control, (B)Control+vitamin E plus C, (C)Hyperfibrinogenemia and (D)Hyperfibrinogenemia+vitamins E plus C. Hyperfibrinogenemia induced by daily injection of adrenaline (0.1mg/day/rat) for 120 days. TREATMENT 3.42 mg/kg of vitamin E plus 2.14 mg/kg of vitamin C, fifteen days after induction. Vascular histology analyzed by optical microscopy. Fibrinogen, nitrites and superoxide dismutase analyzed by spectrophotometry. STATISTICS MANOVA, Hotelling test for post testing, significance level p |
| Databáze: | OpenAIRE |
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