Neurodevelopmental Outcomes of Children Following In Utero Exposure to Zika in Nicaragua
| Autor: | Evelin Martinez, Bryan Blette, Marlen Morales, Omar Zepeda, Michael J. Boivin, Filemon Bucardo, Christian Eduardo Toval Ruiz, Sylvia Becker-Dreps, Michael G. Hudgens, Natalie M. Bowman, Barbara D. Goldman, Jeffrey S. A. Stringer, Shiara Ortiz-Pujols, Elizabeth M. Stringer, Daniel Westreich, Matthew H. Collins, Aravinda M. de Silva, Meylin Chavarria, Itziar Familiar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty Nicaragua Asymptomatic Zika virus 03 medical and health sciences 0302 clinical medicine Zika children Pregnancy medicine Humans Medical history 030212 general & internal medicine Prospective Studies Pregnancy Complications Infectious Prospective cohort study Online Only Articles Child biology business.industry Zika Virus Infection Infant Newborn Gestational age neurodevelopmental outcome Infant Zika Virus Anthropometry biology.organism_classification Infectious Diseases AcademicSubjects/MED00290 In utero Female medicine.symptom business Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Neurodevelopmental outcomes of asymptomatic children exposed to Zika virus (ZIKV) in utero are not well characterized. Methods We prospectively followed 129 newborns without evidence of congenital Zika syndrome (CZS) up to 24 months of age. Participants were classified as ZIKV exposed or ZIKV unexposed. The Mullen Scales of Early Learning (MSEL) was administered in the participants’ homes at 6, 12, 15, 18, 21, and 24 months of age by trained psychologists. Sociodemographic data, medical history, and infant anthropometry at birth were collected at each home visit. Our primary outcome was the Mullen Early Learning Composite Score (ECL) at 24 months of age between our 2 exposure groups. Secondary outcomes were differences in MSEL subscales over time and at 24 months. Results Of 129 infants in whom exposure status could be ascertained, 32 (24.8%) met criteria for in utero ZIKV exposure and 97 (75.2%) did not. There were no differences in maternal age, maternal educational attainment, birthweight, or gestational age at birth between the 2 exposure groups. The adjusted means and standard errors (SEs) for the ELC score between the ZIKV-exposed children compared to ZIKV-unexposed children were 91.4 (SE, 3.1) vs 96.8 (SE, 2.4) at 12 months and 93.3 (SE, 2.9) vs 95.9 (SE, 2.3) at 24 months. In a longitudinal mixed model, infants born to mothers with an incident ZIKV infection (P = .01) and low-birthweight infants ( Children with in utero Zika virus exposure and without congenital Zika syndrome in Nicaragua had lower neurocognitive scores at 24 months. Our study includes multiple evaluations over time and a contemporary nonexposed comparator group of children, which is currently lacking in the literature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|