Does the extension of the type of hysterectomy contribute to the local control of endometrial cancer?
| Autor: | Mikiko Asai-Sato, Aiko Yashiro-Kawano, Haruya Saji, Hiroyuki Shigeta, Emi Ohnuma, Masakazu Kitagawa, Yasuyo Maruyama, Yuka Oi, Yuko Mine, Hanako Taniguchi, Megumi Furugori, Ken Sugiura, Kazumi Kubota, Tatsuya Matsunaga, Reiko Numazaki, Hisamori Kato, Etsuko Miyagi, Keiko Segawa, Tetsuya Hasegawa |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Multivariate analysis medicine.medical_treatment Urology Type of hysterectomy Kaplan-Meier Estimate Hysterectomy 03 medical and health sciences 0302 clinical medicine Endometrial cancer Surgical oncology medicine Adjuvant therapy Local recurrence Humans Stage (cooking) Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Hematology General Medicine Middle Aged medicine.disease Confidence interval Endometrial Neoplasms 030104 developmental biology Treatment Outcome Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Surgery Female Original Article Neoplasm Recurrence Local business |
| Zdroj: | International Journal of Clinical Oncology |
| ISSN: | 1437-7772 |
| Popis: | Objective To examine the necessity and sufficiency of different types of hysterectomy for the surgical treatment of endometrial cancer. Methods This was a multicenter collaborative study conducted by 11 institutions. Among patients with stage I–III endometrial cancer who underwent surgery as the initial treatment (only chemotherapy was provided if adjuvant therapy was needed) from 2001 to 2012, we retrospectively examined the type of hysterectomy, clinicopathological factors, recurrence rate over a maximum period of 5 years, and the site of recurrence. The local recurrence rate was examined by univariate and multivariate analyses. Results Among 1335 patients, 982 (73.6%) underwent simple hysterectomy (SH) and 353 (26.4%) underwent modified radical hysterectomy (mRH) and were observed for a mean duration of 51.8 months. No significant difference was observed in the rate of local recurrence between the SH and mRH groups (p = 0.928). In multivariate analysis, clinicopathological factors independently associated with localized recurrence included postmenopausal status [hazard ratio (HR) 5.036, 95% confidence interval (CI) 1.506–16.841, p = 0.009], with stages II (HR 3.337, 95% CI 1.701–6.547, p |
| Databáze: | OpenAIRE |
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