Obesity and Depression: Shared Pathophysiology and Translational Implications
| Autor: | Lucile Capuron, Nathalie Castanon, Bruno Aouizerate, Lison Huet, Ines Delgado |
|---|---|
| Přispěvatelé: | Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique |
| Rok vydání: | 2019 |
| Předmět: |
[SDV.GEN]Life Sciences [q-bio]/Genetics
business.industry [SDV]Life Sciences [q-bio] medicine.disease Obesity Pathophysiology 3. Good health [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics Mood disorders Close relationship medicine Obese subjects Biological psychiatry business Depression (differential diagnoses) Clinical psychology Management of depression |
| Zdroj: | Neurobiology of Depression: Road to Novel Therapeutics : Road to Novel Therapeutics Neurobiology of Depression: Road to Novel Therapeutics : Road to Novel Therapeutics, Academic press, Elsevier, 471 p., 2019, 978-0-12-813333-0. ⟨10.1016/B978-0-12-813333-0.00016-0⟩ |
| DOI: | 10.1016/b978-0-12-813333-0.00016-0 |
| Popis: | Chapitre 16; International audience; There is mounting evidence for a close relationship between obesity and depression. Depression is frequent in obese subjects and, in turn, obesity is associated with a greater risk of depression. Moreover, recent data suggest a role for obesity in treatment-resistant depression. While the association is bidirectional, the paths and mechanisms by which obesity can lead to depression appear to be particularly relevant to biological psychiatry, as they can provide new information on the pathophysiology and treatment of mood disorders. This chapter will review those pathophysiological pathways and processes that are shared by obesity and depression and that are likely to underlie the intricate relationship between the two disorders. Their potential translational implications and relevance to the development of personalized strategies for the treatment and management of depression will be further discussed. |
| Databáze: | OpenAIRE |
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