Cancer stem cells: A comprehensive review on identification and therapeutic implications
| Autor: | P Jayanthi, Pratibha Ramani, B R Varun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Homeobox protein NANOG markers Review Article Biology self-renewal Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine SOX2 Cancer stem cell medicine Progenitor cell General Dentistry Cancer stem cells CD44 Cancer medicine.disease stomatognathic diseases 030104 developmental biology Otorhinolaryngology 030220 oncology & carcinogenesis Cancer cell Cancer research biology.protein Stem cell |
| Zdroj: | Journal of Oral and Maxillofacial Pathology : JOMFP |
| ISSN: | 1998-393X 0973-029X |
| Popis: | Cancer stem cells (CSCs) are distinct subpopulations of tumor cells that possess the ability for perpetual self-renewal and proliferation. They produce downstream progenitor cells and cancer cells that drive tumor growth. Studies of many cancer types including oral squamous cell carcinoma (OSCC) have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This is compounded further by the presence of multiple CSC subtypes within OSCC, making investigation reliant on the use of multiple markers. This review paper focuses on the current knowledge in CSC markers including OCT4, SOX2, NANOG, aldehyde dehydrogenase 1, CD44, CD24, CD133 and Musashi-1, highlighting their use and validity in OSCC CSC research. |
| Databáze: | OpenAIRE |
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