Stability of serum interleukin-10 levels during the menstrual cycle
| Autor: | Alexandra I. F. Blakemore, Susan Laird, Joanna K. Maskill, M.A. Okon, Tin-Chiu Li |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors media_common.quotation_subject medicine.medical_treatment Immunology Biology Luteal phase Luteal Phase Pregnancy Internal medicine medicine Immunology and Allergy Humans Menstrual cycle Menstrual Cycle Progesterone media_common Confounding Obstetrics and Gynecology Interleukin medicine.disease Interleukin-10 Interleukin 10 Endocrinology Cytokine Reproductive Medicine Follicular Phase Female Luteinizing hormone Interleukin-1 |
| Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989). 38(5) |
| ISSN: | 1046-7408 |
| Popis: | PROBLEM: Menstrual cycle-associated variability in the circulating levels of several cytokines can be a confounding factor in measurements of in vivo cytokine levels in clinical studies. Since pregnancy-associated increases in interleukin-10 (IL-10) levels are well documented, we have investigated the variability in serum levels of IL-10 in healthy women at different stages of the menstrual cycle to ascertain whether this is a problem in comparative studies of circulating IL-10 levels. METHOD OF STUDY: We obtained fifty-four successive serum samples at points in the menstrual cycles of 12 healthy fertile women, precisely timed by measurement of the luteinizing hormone surge, and measured the interleukin-10 levels. RESULTS: Levels of IL-10 in successive serum samples from each woman taken on days LH-7 (that is seven days prior to LH surge), LH-4, LH+1, LH+7, and LH+10 showed that IL-10 does not vary in a systematic way during the menstrual cycle. CONCLUSION: These results validate the sampling of women in studies of IL-10 levels in various clinical situations and establish that these levels are not dependent on menstrual cycle dates. They also suggest that menstrual cycle-related changes in IL-1 are not mediated by IL-10. The rise in progesterone in the luteal phase of the menstrual cycle is not mirrored by a rise in the circulating IL-10 level, which implies either that the pregnancy-associated rise is not related to progesterone or that it is only observed at the higher progesterone levels in pregnancy. |
| Databáze: | OpenAIRE |
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