Synthesis, structural elucidation and pharmacological properties of some 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones
| Autor: | Kevser Erol, Mine Yarim, Mevlüt Ertan, Selma Saraç, Batu Os |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Muscle Relaxation Acetylacetone Barium Compounds Biginelli reaction Pharmaceutical Science Pyrimidinones In Vitro Techniques Chemical synthesis Mass Spectrometry chemistry.chemical_compound Chlorides Ileum Drug Discovery Animals Organic chemistry Barium chloride Carbon-13 NMR Calcium Channel Blockers Rats chemistry Proton NMR Urea Spectrophotometry Ultraviolet |
| Zdroj: | Il Farmaco. 54:359-363 |
| ISSN: | 0014-827X |
| DOI: | 10.1016/s0014-827x(99)00042-7 |
| Popis: | In this study, the synthesis of some new 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones has been reported. The compounds were prepared by the Biginelli reaction of acetylacetone with aromatic aldehydes and urea. The structures of the compounds were characterized by UV, IR, 1H NMR, 13C NMR, mass spectra and elementary analysis. The calcium antagonistic activity of these compounds was tested in vitro on rat ileum precontracted with 4×10−3 M barium chloride. |
| Databáze: | OpenAIRE |
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