Immunisation against lactic acidosis in cattle

Autor: S.H. Bird, Ronald Leng, H.S. Gill, D.W. Hennessy, Q. Shu, James Rowe
Rok vydání: 1999
Předmět:
Zdroj: Research in Veterinary Science. 67:65-71
ISSN: 0034-5288
DOI: 10.1053/rvsc.1998.0284
Popis: The present study was designed to investigate the efficacy of control of lactic acidosis by immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus. Ten steers were allocated to two treatment groups. One group was immunised with a vaccine containing S. bovis (strain Sb-5) and Lactobacillus (LB-27) cells, and the other was a non-immunised control group. The vaccine, using Freund's complete adjuvant for primary immunisation and Freund's incomplete adjuvant for boosters, was administered intramuscularly. After primary immunisation, boosters were given at 2 to 4 week intervals. Both anti- S. bovis and anti- Lactobacillus IgG levels in saliva increased significantly (P0.01) after the 1st booster which were lower (P0.05) than the IgG levels after the 2nd and 3rd boosters, but were not significantly different (P0.05) from the IgG levels prior to a grain challenge (after the 4th booster). There were positive correlations between the anti- S.bovis and anti- Lactobacillus IgG in serum and saliva. Compared with the control group, steers in the immunised group had higher (P0.05) feed intakes, lower (P0.05) rumen concentrations of lactate and lower numbers of S. bovis and Lactobacillus. Three of the control animals were withdrawn from the grain challenge due to their rumen pH persisting below 5.2, while only one animal in the immunised group was withdrawn. These results suggest that the risk of lactic acidosis can be reduced by immunisation against S. bovis and Lactobacillus.
Databáze: OpenAIRE
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