Changes in erythropoietin and haemoglobin concentrations in response to saturation diving
| Autor: | Rune J. Ulvik, Arvid Hope, K Segadal, Dag Hofsø, Einar Thorsen |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Bilirubin Diving Hyperoxia Blood cell chemistry.chemical_compound Hemoglobins Physiology (medical) Internal medicine medicine Humans Orthopedics and Sports Medicine Erythropoietin biology Haptoglobins Haptoglobin Public Health Environmental and Occupational Health General Medicine Middle Aged Haemolysis Blood Cell Count Ferritin medicine.anatomical_structure Endocrinology chemistry Immunology Ferritins biology.protein Hemoglobin medicine.symptom human activities medicine.drug |
| Zdroj: | European journal of applied physiology. 95(2-3) |
| ISSN: | 1439-6319 |
| Popis: | A reduction in haemoglobin concentration is consistently reported after deep saturation dives. This may be due to a downregulation of erythropoietin (EPO) concentration or to a toxic effect of the hyperoxia associated with the dives resulting in an increased destruction rate of erythrocytes. In this study haemoglobin concentration, blood cell counts, serum ferritin, bilirubin, haptoglobin and EPO concentrations were measured before, during and after a 19 day saturation dive to 240 m. The partial pressure of oxygen (PO(2)) was 35-70 kPa during the 7 day compression and bottom phase, and 30-50 kPa during the 12 day decompression phase. There was a reduction in EPO concentration from 8.4+/-1.4 (mean +/- 1SD) to 6.3 +/- 1.9 U.L(-1) on Dive day 2. On Dive days 7 and 17 EPO concentrations were not significantly different from baseline despite the continued exposure to hyperoxia. Immediately after the dive and return to a normoxic environment there was an increase in the EPO concencentration to 14.5 +/- 4.7 U.L(-1). Haemoglobin concentration, erythrocyte and reticulocyte counts were decreased at the end of the dive, and there was an increase in serum ferritin. There were no changes in bilirubin or haptoglobin concentrations indicative of haemolysis. It appears that the change in PO(2), rather than the sustained exposure to a hyperoxic environment, induces the changes in the EPO concentrations and erythropoietic activity. |
| Databáze: | OpenAIRE |
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