The effect of heat exposure on blood chemistry of the hyperthermic rabbit
| Autor: | R Sharir, Jacob Marder, U Eylath, E Moskovitz |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Hyperthermia
Male medicine.medical_specialty Hot Temperature Fever Acid–base homeostasis Electrolytes Hypocapnia Internal medicine medicine Animals Acidosis Chemistry Osmolar Concentration Metabolic acidosis General Medicine Hypothermia Hydrogen-Ion Concentration medicine.disease Alkaline Phosphatase Endocrinology Cholesterol Blood chemistry Alkaline phosphatase Female Rabbits medicine.symptom Blood Chemical Analysis |
| Zdroj: | Comparative biochemistry and physiology. A, Comparative physiology. 97(2) |
| ISSN: | 0300-9629 |
| Popis: | 1. 1. Two hours of exposure to heat stress, resulted in hyperthermia in rabbits (Orictolagus cuniculus). 2. 2. This was accompanied by a severe hypocapnia, partly compensated for by a significant decrease in bicarbonate (HCO−3) concentration. 3. 3. The severest hyperthermia (Tb = 43.5°) was followed by a sharp decrease in both PaCO2 (to 20.2 ton) and HCO−3 (to 9.2 mM/l), resulting in extreme metabolic acidosis (pH = 7.290). 4. 4. The significant increase in serum osmolality (27%) is interpreted by the cumulative effect of increased electrolyte and metabolite concentrations. 5. 5. The elevation in blood BUN, creatinine, globulin and GOT levels point to a possible damage to muscle cells by hypothermia. 6. 6. The stable cholesterol and alkaline phosphatase levels, suggest that liver tissue was not damaged. 7. 7. The dramatic increase in glucose from 103.8 to 348.8 mg%, and the significant increase (from 22.0 to 39,9 mg%) in BUN, suggest a possible disability of the cells to metabolize carbohydrates, accompanied by a progressive proteolysis as an alternative process for energy production. 8. 8. The data suggest that the emergence of muscle cell damage, severe hyperglycemia and acidosis under heat stress, precedes and amplifies the deteriorating effects of high tb in heat stressed rabbits, which often lead to mortality. |
| Databáze: | OpenAIRE |
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