FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
| Autor: | Pat Levitt, Ryan J. Kast, Colton Smith, Alexandra L Lanjewar |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Mouse Gene Expression Histogenesis 0302 clinical medicine Cortex (anatomy) Biology (General) Cerebral Cortex Neurons cell fate 0303 health sciences axon guidance General Neuroscience Forkhead Transcription Factors FOXP2 General Medicine Phenotype neurogenesis medicine.anatomical_structure cortex Expression (architecture) Gene Knockdown Techniques Medicine Research Article QH301-705.5 Science Cell fate determination Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences medicine Animals development Gene Transcription factor 030304 developmental biology General Immunology and Microbiology Mice Inbred C57BL Repressor Proteins 030104 developmental biology Forebrain Axon guidance Developmental biology Neuroscience 030217 neurology & neurosurgery Function (biology) Developmental Biology |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| Popis: | The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized in mice. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many functions that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought. |
| Databáze: | OpenAIRE |
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